obecabtagene autoleucel

{
  "id": "MLC-T-ONC-005991",
  "term": "obecabtagene autoleucel",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with acute lymphoblastic leukemia that came back or did not get better during or after other treatment. It is also being studied in the treatment of other conditions and types of cancer. Obecabtagene autoleucel is made using a patient’s T cells (a type of immune system cell). A gene for a special receptor called chimeric antigen receptor (CAR) is added to the T cells in the laboratory. These changed T cells called CAR T cells are grown in large numbers in the laboratory and given to the patient by infusion. Obecabtagene autoleucel binds to a protein called CD19, which is found on some leukemia cells. This helps the body’s immune system kill cancer cells. Obecabtagene autoleucel is a type of CAR T-cell therapy. Also called Aucatzyl.",
    "A preparation of autologous T lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a second-generation chimeric antigen receptor (CAR), CAT-41BBz CAR, targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, obecabtagene autoleucel target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The CAT-41BBz CAR has a faster off-rate compared with FMC63-41BBz CAR. This may minimize cytokine release and reduce toxicities, and enhance persistence of the CAR T cells."
  ],
  "synonyms": [
    "Aucatzyl",
    "AUTO1 CAR-T cells",
    "autologous anti-CD19 CAR T cells AUTO1",
    "autologous anti-CD19 chimeric antigen receptor T lymphocytes AUTO1",
    "autologous CD19-targeted CAR T cells AUTO1",
    "CD19CAR T cells AUTO1",
    "CD19CAT-41BBZ CAR T cells AUTO1",
    "obe-cel"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/obecabtagene-autoleucel/"
}