oncolytic HSV-1716

{
  "id": "MLC-T-ONC-015645",
  "term": "oncolytic HSV-1716",
  "field": "Oncology and biomedicine",
  "definition": "A neuroattenuated, replication-restricted, ICP34.5 deleted (RL1 gene)-mutant herpes simplex virus (HSV) type I, constructed from wild-type strain 17, with potential oncolytic activity. Upon intratumoral injection, oncolytic HSV1716 transfects, replicates in, and lyses rapidly dividing cells such as tumor cells. Because the RL1 gene is deleted , HSV1716 is unable to replicate in non-dividing cells.",
  "synonyms": [
    "herpes simplex virus 1716"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/oncolytic-hsv-1716/"
}