onvatilimab

{
  "id": "MLC-T-ONC-015674",
  "term": "onvatilimab",
  "field": "Oncology and biomedicine",
  "definition": "A human monoclonal antibody against the protein V-domain immunoglobulin (Ig) suppressor of T-cell activation (VISTA; programmed death 1 homolog; PD1H; PD-1H), with potential negative checkpoint regulatory and antineoplastic activities. Upon administration, onvatilimab targets and binds to VISTA. This inhibits VISTA signaling, abrogates the VISTA-induced suppression of T-lymphocyte-mediated immune responses, enhances cytotoxic T-cell responses against tumor cells and inhibits tumor cell growth. VISTA, mainly expressed on hematopoietic cells, plays a key role in immunosuppression.",
  "synonyms": [
    "immunoglobulin G1, anti-(human protein Vista (v-domain immunoglobulin suppressor of T cell activation)) (human clone JNJ 61610588 gamma1-chain), disulfide with human clone JNJ",
    "WHO 10758"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/onvatilimab/"
}