p21 gene activator saRNA RAG-01

{
  "id": "MLC-T-ONC-015742",
  "term": "p21 gene activator saRNA RAG-01",
  "field": "Oncology and biomedicine",
  "definition": "A small activating RNA (saRNA) targeting the tumor suppressor gene p21, with potential antineoplastic activity. Upon intravesical instillation of p21 gene activator saRNA RAG-01, the saRNA targets and activates the expression of the p21 gene and restores p21 therapeutic protein levels. This may decrease bladder tumor cell growth. Downregulation of p21 plays a key role in tumorigenesis. p21 is crucial for regulating the progression of the cell cycle and plays an essential role in halting the proliferation of cancer cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/p21-gene-activator-sarna-rag-01/"
}