p38 MAPK inhibitor LY3007113

{
  "id": "MLC-T-ONC-015747",
  "term": "p38 MAPK inhibitor LY3007113",
  "field": "Oncology and biomedicine",
  "definition": "An orally active p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activity. Upon administration, LY3007113 inhibits the activity of p38, thereby preventing p38 MAPK-mediated signaling. This may result in the inhibition of the production of proinflammatory cytokines and the induction of tumor cell apoptosis. p38 MAPK, a serine/threonine protein kinase often upregulated in cancer cells, plays a crucial part in the production of a variety of cytokines involved in inflammation and cellular proliferation such as tumor necrosis factor (TNF) and interleukin (IL)-1 and -6.",
  "synonyms": [
    "p38 mitogen-activated protein kinase inhibitor LY3007113"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/p38-mapk-inhibitor-ly3007113/"
}