Paromomycin sulfate

{
  "id": "MLC-T-ONC-015833",
  "term": "Paromomycin sulfate",
  "field": "Oncology and biomedicine",
  "definition": "The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death.",
  "synonyms": [
    "paramomycin sulfate",
    "aminosidine sulfate",
    "humycin sulfate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/paromomycin-sulfate/"
}