Paroxetine hydrochloride

{
  "id": "MLC-T-ONC-006357",
  "term": "Paroxetine hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI). Also called Paxil.",
    "The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness."
  ],
  "synonyms": [
    "Paxil"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/paroxetine-hydrochloride/"
}