Pazopanib hydrochloride

{
  "id": "MLC-T-ONC-006400",
  "term": "Pazopanib hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with advanced renal cell carcinoma (a type of kidney cancer) or advanced soft tissue sarcoma that has already been treated with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Pazopanib hydrochloride blocks certain proteins, which may prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent. Also called GW786034 and Votrient.",
    "The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated."
  ],
  "synonyms": [
    "GW786034",
    "Votrient"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pazopanib-hydrochloride/"
}