Pemetrexed disodium

{
  "id": "MLC-T-ONC-006470",
  "term": "Pemetrexed disodium",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with other drugs to treat certain types of non-small cell lung cancer and malignant pleural mesothelioma. It is also being studied in the treatment of other types of cancer. Pemetrexed disodium stops cells from using folic acid to make DNA and may kill cancer cells. It is a type of antimetabolite and a type of antifolate. Also called Alimta, LY231514, and Pemfexy.",
    "The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis."
  ],
  "abbreviation": "MTA",
  "synonyms": [
    "Alimta",
    "LY231514",
    "Pemfexy",
    "multitargeted antifolate"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pemetrexed-disodium/"
}