Peutz-Jeghers syndrome

{
  "id": "MLC-T-ONC-006562",
  "term": "Peutz-Jeghers syndrome",
  "field": "Oncology and biomedicine",
  "definition": "A rare genetic disorder in which many polyps (abnormal growths of tissue) form in the lining of the gastrointestinal tract, and dark-colored spots appear on certain areas of the skin, such as around the mouth, eyes, and nose. People with Peutz-Jeghers syndrome have a very high risk of developing gastrointestinal cancer and other types of cancer, including cancers of the breast, pancreas, ovary, lung, and cervix. Peutz-Jeghers syndrome is usually caused by mutations (changes) in the STK11 gene. Some people with Peutz-Jeghers syndrome do not have a mutation in the STK11 gene. In these cases, the cause of the disorder is unknown. Also called PJS.",
  "synonyms": [
    "PJS"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/peutz-jeghers-syndrome/"
}