Pevonedistat

{
  "id": "MLC-T-ONC-006563",
  "term": "Pevonedistat",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of some types of cancer. Pevonedistat blocks an enzyme called NEDD8-activating enzyme (NAE), which is involved in cell division. Blocking this enzyme may help keep cancer cells from growing and may kill them. Pevonedistat is a type of NAE inhibitor and a type of targeted therapy.",
    "A small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. Pevonedistat binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). Functioning in diverse regulatory activities, proteins conjugated to UBLs like Nedd8 typically are not targeted for proteasomal degradation."
  ],
  "synonyms": [
    "NAE inhibitor MLN4924",
    "Nedd8-activating enzyme inhibitor MLN4924"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pevonedistat/"
}