PI3K/mTOR inhibitor CLL442

{
  "id": "MLC-T-ONC-016053",
  "term": "PI3K/mTOR inhibitor CLL442",
  "field": "Oncology and biomedicine",
  "definition": "A topical inhibitor of class I phosphoinositide 3-kinase (PI3K) isoforms and mammalian target of rapamycin kinase (mTOR), with potential antineoplastic activity. Upon topical administration, PI3K/mTOR inhibitor CLL442 targets and inhibits class I PI3K isoforms and mTOR kinase. This disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells. The PI3K/mTOR pathway is upregulated in a variety of tumor cells and plays a key role in promoting cancer cell proliferation, survival and motility.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pi3k-mtor-inhibitor-cll442/"
}