Plasmodium vivax-infected red blood cells

{
  "id": "MLC-T-ONC-016108",
  "term": "Plasmodium vivax-infected red blood cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of red blood cells (RBCs) that have been infected with the malaria parasite Plasmodium vivax (P. vivax), with potential immunomodulating and antineoplastic activities. Upon administration of the P. vivax-infected RBCs, the P. vivax infection stimulates host immune responses against the P. vivax-infected RBCs. This also stimulates both innate and adaptive anti-tumor immune responses. This leads to the production of cytokines, including interferon-gamma (IFN-g) and tumor-necrosis factor alpha (TNF-a), the proliferation and activation of natural killer (NK) cells, dendritic cells (DCs), CD4-positive T lymphocytes, and cytotoxic T lymphocytes (CTLs). This results in the inhibition of tumor cell proliferation, induction of tumor cell apoptosis, and prevents angiogenesis.",
  "synonyms": [
    "P. vivax-infected red blood cells",
    "P. vivax-infected RBCs",
    "Plasmodium vivax RBC immunotherapy agent"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/plasmodium-vivax-infected-red-blood-cells/"
}