preimplantation factor PIF-1

{
  "id": "MLC-T-ONC-016211",
  "term": "preimplantation factor PIF-1",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic version, known as PIF-1, of the peptide preimplantation factor (PIF), an embryo-secreted peptide, with potential activity against graft-versus-host disease (GVHD). PIF-1 is believed to have wide-ranging activity on the immunologic system, including a whole host of immunologic changes that resemble pregnancy, in which there is neither graft-versus-host or host-versus-graft disease between the mother and the embryo. Replication of the immunologic profile of pregnancy through the administration of PIF-1 may thus benefit patients undergoing bone marrow transplant (BMT) who experience graft-versus-host disease (GVHD). Native embryonic PIF has been found to have a multi-targeted effect on various aspects of the immune system, coordinated so that there is a successful embryonic implantation and a successful pregnancy.",
  "abbreviation": "PIF-1",
  "synonyms": [
    "PIF-1 peptide"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/preimplantation-factor-pif-1/"
}