Protopine/nuciferine supplement

{
  "id": "MLC-T-ONC-016267",
  "term": "Protopine/nuciferine supplement",
  "field": "Oncology and biomedicine",
  "definition": "A nutritional supplement composed of the two alkaloids protopine, a benzylisoquinoline alkaloid occurring in opium poppies and other plants of the Papaveraceae family, and nuciferine, an alkaloid component of Nelumbo nucifera and Nymphaea caerulea, and in certain plants of the Papaveraceae family, with antihistamine, anticholinergic, analgesic, smooth muscle relaxing, central nervous system (CNS) suppressing and antipsychotic-like activities. Upon administration, protopine inhibits histamine H1 receptors and exerts opioid analgesic and sedative effects. As an antispasmodic, nuciferine relaxes smooth muscle cells and prevents smooth muscle contractions. It also has a calming effect. Together, protopine and nuciferine may relax the bladder and reduce urinary urgency and frequency, thereby providing relief for urge incontinence. It may also ease bladder pain and irritation.",
  "synonyms": [
    "protopine and nuciferine supplement",
    "protopine/nuciferine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/protopine-nuciferine-supplement/"
}