PTTC topical ointment ACU-D1

{
  "id": "MLC-T-ONC-016291",
  "term": "PTTC topical ointment ACU-D1",
  "field": "Oncology and biomedicine",
  "definition": "A topical ointment formulation containing pentaerythritol tetrakis (3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate) (PTTC), an inhibitor of the 26S proteasome, with potential antiangiogenic and antineoplastic activities. Upon topical administration of the PTTC topical ointment ACU-D1, PTTC inhibits the activity of the 26S proteasome, blocking the targeted proteolysis normally performed by the proteasome and resulting in an accumulation of unwanted or misfolded proteins. This disrupts various cell signaling pathways and may lead to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated.",
  "synonyms": [
    "proteasome inhibitor ointment ACU-D1",
    "PTTC-based topical ointment ACU-D1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pttc-topical-ointment-acu-d1/"
}