rasburicase

{
  "id": "MLC-T-ONC-007224",
  "term": "rasburicase",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat high levels of uric acid in the blood of adults and children with leukemia, lymphoma, or other types of cancer who are receiving certain types of anticancer therapy. Uric acid is a natural substance that can build up in the blood as tumors break down. Rasburicase helps break down and remove uric acid from the body. It is a type of recombinant enzyme and a type of urate-lowering drug. Also called Elitek and recombinant urate oxidase.",
    "A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisae. Urate oxidase catalyzes the oxidation of uric acid to the excretable mebolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans."
  ],
  "synonyms": [
    "Elitek",
    "recombinant urate oxidase",
    "Urate Oxidase"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rasburicase/"
}