RevM10 gene

{
  "id": "MLC-T-ONC-007418",
  "term": "RevM10 gene",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An antiviral gene that is being studied in the treatment of cancer in patients who have HIV, the virus that causes AIDS.",
    "RevM10 is a dominant-negative mutant of HIV-1 Rev gene, which encodes a RNA-binding protein involving in nuclear trafficking of unspliced viral mRNAs. Due to the fact that Rev is essential for HIV-1 replication makes it an attractive target for antiviral approaches. Based on the notion of intracellular immunization, in vitro studies that introducing RevM10 gene into stem cells have demonstrated its ability to combat HIV-1 infection in human hematopoietic cells."
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/revm10-gene/"
}