sabatolimab

{
  "id": "MLC-T-ONC-016613",
  "term": "sabatolimab",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, sabatolimab binds to TIM-3 expressed on certain immune cells, including tumor infiltrating lymphocytes (TILs). This abrogates T-cell inhibition, activates antigen-specific T lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis resulting in a reduction in tumor growth. TIM-3, a transmembrane protein expressed on certain T cells, is associated with tumor-mediated immune suppression.",
  "synonyms": [
    "anti-TIM-3 monoclonal antibody MBG453",
    "anti-TIM3 checkpoint inhibitor MBG453"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/sabatolimab/"
}