shark cartilage extract AE-941

{
  "id": "MLC-T-ONC-016703",
  "term": "shark cartilage extract AE-941",
  "field": "Oncology and biomedicine",
  "definition": "A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cell receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.",
  "synonyms": [
    "Neovastat/AE-941"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/shark-cartilage-extract-ae-941/"
}