Sodium-potassium adenosine triphosphatase inhibitor RX108

{
  "id": "MLC-T-ONC-016814",
  "term": "Sodium-potassium adenosine triphosphatase inhibitor RX108",
  "field": "Oncology and biomedicine",
  "definition": "A small-molecule, inhibitor of sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) with potential antineoplastic activity. Upon administration, RX108 inhibits the activity of the Na+/K+-ATPase, which prevents the activation of various signal transduction pathways that play a key role in tumor proliferation. This may lead to cell-cycle arrest, apoptosis, and autophagic cell death. Na+/K+-ATPase is overexpressed in certain tumor types and may serve as a scaffold for the assembly of multiple-protein signaling complexes that regulate cell proliferation and motility. In normal, healthy cells, the Na+/K+-ATPase controls transportation of Na+ and K+ across the cell membrane and is essential for electrochemical gradient maintenance, osmotic balance, and cellular pH.",
  "synonyms": [
    "Na+/K+-ATPase inhibitor RX108",
    "sodium-potassium pump inhibitor RX108"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/sodium-potassium-adenosine-triphosphatase-inhibitor-rx108/"
}