Spherical nucleic acid nanoparticle NU-0129

{
  "id": "MLC-T-ONC-016843",
  "term": "Spherical nucleic acid nanoparticle NU-0129",
  "field": "Oncology and biomedicine",
  "definition": "A spherical nucleic acid (SNA) gold nanoparticle formulation composed of small interfering RNAs (siRNAs) targeting the Bcl-2-like protein 12 (BCL2L12) sequence and conjugated to gold nanoparticles, with potential antineoplastic activity. Upon administration of SNA NU-0129, the siRNA prevents the translation of the BCL2L12 gene. Inhibiting the expression of BCL2L12 by NU-0129 induces tumor cell apoptosis. Bcl2L12, a protein belonging to the Bcl-2 protein family, is overexpressed in glioblastoma multiforme (GBM) and plays a role in tumor cell progression and tumor cell resistance to apoptosis. NU-0129 is able to cross the blood brain barrier (BBB).",
  "synonyms": [
    "SNA gold nanoparticle NU-0129",
    "SNA NU-0129"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/spherical-nucleic-acid-nanoparticle-nu-0129/"
}