STAT3 dual phosphorylation site inhibitor YY201

{
  "id": "MLC-T-ONC-016867",
  "term": "STAT3 dual phosphorylation site inhibitor YY201",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. Upon oral administration, STAT3 dual phosphorylation site inhibitor YY201 targets, binds to and inhibits Tyr705 and Ser727 double-site phosphorylation of STAT3, thereby inhibiting the function of STAT3. This prevents STAT3 binding to responsive gene promoters, STAT3-mediated signaling and the expression of STAT3 target genes. This inhibits the proliferation of STAT3-overexpressing tumor cells. STAT3 regulates the transcription of genes involved in several cellular functions. STAT3 is constitutively activated in a variety of human cancers and plays a key role in neoplastic transformation, uncontrolled tumor cell proliferation, resistance to apoptosis, metastasis, immune evasion, tumor angiogenesis, epithelial-mesenchymal transition (EMT) and the Warburg effect.",
  "synonyms": [
    "STAT3 inhibitor YY201"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/stat3-dual-phosphorylation-site-inhibitor-yy201/"
}