Sulindac

{
  "id": "MLC-T-ONC-008380",
  "term": "Sulindac",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer.",
    "A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death."
  ],
  "abbreviation": "SULIN",
  "synonyms": [
    "Sulindac Sulfoxide"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/sulindac/"
}