synthetic human secretin

{
  "id": "MLC-T-ONC-008453",
  "term": "synthetic human secretin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to help diagnose gastrinomas (tumors that cause too much gastric acid to be made) and other problems with the pancreas. It is also used to increase secretions from the pancreas and to help identify a duct called the ampulla of Vater. Synthetic human secretin is a form of secretin that is made in the laboratory. Secretin causes the pancreas, liver, and stomach to release substances that help digest food. Also called ChiRhoStim and secretin human.",
    "A synthetic human therapeutic agent which is chemically identical or similar to endogenous secretin, a peptide hormone found in the mucosal S-cells of the proximal small intestine. Secretin stimulates the pancreatic acinar cells and ductal epithelial cells to emit bicarbonate rich digestive fluids, thereby increases duodenal bicarbonate level. Bicarbonate neutralizes acidity of the intestines, consequently increasing the pH and facilitating the action of intestinal digestive enzymes. In addition, secretin stimulates the stomach and the liver to produce pepsin and bile, respectively. Both pepsin and bile aide the digestive action of the duodenum, which resulting in the prevention of gastric inflammation."
  ],
  "abbreviation": "SHS",
  "synonyms": [
    "ChiRhoStim",
    "secretin human"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/synthetic-human-secretin/"
}