TBX-4000-treated hematopoietic stem cells TBX-2400

{
  "id": "MLC-T-ONC-016998",
  "term": "TBX-4000-treated hematopoietic stem cells TBX-2400",
  "field": "Oncology and biomedicine",
  "definition": "An allogeneic cell preparation in which donor-derived hematopoietic stem cells (HSCs) are treated ex vivo with TBX-4000, a recombinant TAT-MYC fusion protein, with potential immunoreconstitutive activity. Upon administration, the TBX-4000-treated HSCs TBX-2400 may enhance the engraftment of the bone marrow upon allogeneic hematopoietic stem cells transplant (HSCT). The TBX-4000 recombinant fusion protein consists of the N-terminal 9 amino acid segment of the HIV TAT protein transduction domain (PTD) fused to the MYC protein. TBX-4000 TAT-MYC rapidly localizes to the nucleus and transiently provides signals to drive proliferation and survival of the HSCs.",
  "synonyms": [
    "HSCs TBX-2400"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tbx-4000-treated-hematopoietic-stem-cells-tbx-2400/"
}