temsirolimus

{
  "id": "MLC-T-ONC-008585",
  "term": "temsirolimus",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat advanced renal cell carcinoma (a type of kidney cancer). It is also being studied in the treatment of other types of cancer. Temsirolimus blocks a protein called mTOR, which helps control cell division. Blocking this protein may help keep cancer cells from growing. Temsirolimus is a type of kinase inhibitor. Also called CCI-779 and Torisel.",
    "An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors."
  ],
  "synonyms": [
    "CCI-779",
    "Torisel",
    "cell cycle inhibitor 779",
    "rapamycin analog CCI-779",
    "Rapamycin Analog"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/temsirolimus/"
}