Tetrahydrouridine

{
  "id": "MLC-T-ONC-008622",
  "term": "Tetrahydrouridine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of some types of cancer. It may help make cancer cells easier to kill with radiation therapy. Tetrahydrouridine is a type of radiosensitizing agent, a type of multidrug resistance modulator, and a type of cytidine deaminase inhibitor. Also called THU.",
    "A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2'-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2'-deoxycytidine monophosphate (CldCMP) to 5-chloro-2'-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2'-deoxyuridine)."
  ],
  "abbreviation": "THU",
  "synonyms": [
    "THU"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tetrahydrouridine/"
}