TGF-beta2 antisense oligonucleotide TASO-001

{
  "id": "MLC-T-ONC-017105",
  "term": "TGF-beta2 antisense oligonucleotide TASO-001",
  "field": "Oncology and biomedicine",
  "definition": "A transforming growth factor (TGF)-beta2 specific antisense oligodeoxynucleotide (ASO), with potential antineoplastic activity. Upon administration, TGF-beta2 ASO TASO-001 binds to TGF-beta2 mRNA causing inhibition of protein translation. This decreases TGF-beta2 levels, which may result in the inhibition of tumor cell growth and migration, and tumor angiogenesis. TGF-beta2, a cytokine overexpressed in various malignancies, plays an important role in promoting the growth, progression, and migration of tumor cells.",
  "synonyms": [
    "TGF-beta2-targeting antisense oligonucleotide TASO-001",
    "TGF-beta2 ASO TASO-001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tgf-beta2-antisense-oligonucleotide-taso-001/"
}