anti-IRF4 antisense oligonucleotide ION251

{
  "id": "MLC-T-ONC-010834",
  "term": "anti-IRF4 antisense oligonucleotide ION251",
  "field": "Oncology and biomedicine",
  "definition": "An antisense oligonucleotide (ASO) targeting the interferon regulatory factor 4 (IRF4) mRNA, with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-IRF4 ASO ION251 hybridizes with IRF4 mRNA, which blocks translation of the IRF4 protein. Reduction of IRF4 levels prevents the expression of IRF4-controlled tumor promoter genes, and may enhance tumor cell apoptosis and prevent T-cell exhaustion. IRF4, a transcription factor expressed in lymphocytes and essential for plasma cell differentiation, is involved in immune cell development and plays a key role in T-cell functions. It is overexpressed in certain tumor cell types and is a key regulator of multiple genes controlling tumor cell survival.",
  "synonyms": [
    "IONIS-IRF4-2.5Rx",
    "anti-IRF4 ASO IONIS-IRF4-2.5Rx",
    "anti-IRF4 ASO ION251"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-irf4-antisense-oligonucleotide-ion251/"
}