anti-interleukin-2 receptor subunit gamma monoclonal antibody REGN7257

{
  "id": "MLC-T-ONC-010833",
  "term": "anti-interleukin-2 receptor subunit gamma monoclonal antibody REGN7257",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody targeted against interleukin-2 (IL-2) receptor subunit gamma (IL2RG; CD132; cytokine receptor common subunit gamma; gamma chain; gc), with potential immunomodulatory activity. Upon administration, anti-IL2RG monoclonal antibody REGN7257 targets and binds to the gamma subunit of the human IL-2 receptor (IL-2R) expressed on the surface of activated T lymphocytes, thereby inhibiting IL-2 binding and IL-2-mediated T-cell activation. This may block T-cell-mediated immune responses. IL2RG plays a role in both immune responses and interleukin signaling.",
  "synonyms": [
    "anti-cytokine receptor common subunit gamma monoclonal antibody REGN7257",
    "anti-gamma chain receptor monoclonal antibody REGN7257",
    "anti-IL2RG monoclonal antibody REGN7257"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-interleukin-2-receptor-subunit-gamma-monoclonal-antibody-regn7257/"
}