cimdelirsen

{
  "id": "MLC-T-ONC-012598",
  "term": "cimdelirsen",
  "field": "Oncology and biomedicine",
  "definition": "An antisense oligonucleotide targeting the growth hormone receptor (GHR; somatotropin receptor) mRNA, with potential somatotropin-inhibiting activity. Upon subcutaneous administration, cimdelirsen hybridizes with GHR mRNA, which blocks translation of the GHR protein. Reduction of GHR levels in turn decreases the circulating level of insulin-like growth factor-1 (IGF-1). IGF-1 is a hormone that plays an important role in childhood growth and has anabolic effects in adults. Excess production of IGF-1 results in various disease states including acromegaly.",
  "synonyms": [
    "GHR antisense oligonucleotide IONIS-GHR-LRx",
    "ligand-conjugated antisense drug IONIS-GHR-LRx",
    "LICA drug IONIS-GHR-LRx",
    "IONIS-GHR-LRx",
    "growth hormone receptor antisense oligonucleotide IONIS-GHR-LRx"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cimdelirsen/"
}