Liposomal Bcl-2 antisense oligonucleotide BP1002

{
  "id": "MLC-T-ONC-014813",
  "term": "Liposomal Bcl-2 antisense oligonucleotide BP1002",
  "field": "Oncology and biomedicine",
  "definition": "A liposomal-based nanoparticle composed of an uncharged P-ethoxy antisense oligodeoxynucleotide (ODN) targeting Bcl-2 mRNA and incorporated in liposomes, with potential antineoplastic activity. Upon administration of liposomal Bcl-2 antisense oligonucleotide BP1002, this agent targets and hybridizes with Bcl-2 mRNA and inhibits the expression of Bcl-2 protein. This may induce tumor cell apoptosis of Bcl2-overexpressing tumor cells and may decrease tumor cell proliferation. Bcl2, a protein involved in regulating programmed cell death, is overexpressed in a wide variety of tumors. It promotes cellular survival and inhibits apoptosis.",
  "synonyms": [
    "liposomal Bcl-2 antisense BP1002",
    "L-Bcl-2 antisense oligonucleotide BP1002"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/liposomal-bcl-2-antisense-oligonucleotide-bp1002/"
}