Liposomal c-raf antisense oligonucleotide

{
  "id": "MLC-T-ONC-014817",
  "term": "Liposomal c-raf antisense oligonucleotide",
  "field": "Oncology and biomedicine",
  "definition": "The liposomal formulation of a c-raf-1 antisense oligonucleotide, with potential antineoplastic activity. Liposomal c-raf antisense oligonucleotide targets the translation initiation site of human c-raf-1 mRNA, thereby blocking the expression and production of Raf-1 protein and thus inhibits tumor cell growth and development. Raf-1 plays a key role in the RAF/MEK/ERK signaling pathway, which regulates mammalian cell proliferation and growth. The liposomal formulation increases the solubility of the c-raf antisense oligonucleotide, thus improving its pharmacodynamic profile.",
  "synonyms": [
    "LErafAON",
    "c-raf antisense oligodeoxynucleotide liposome",
    "liposome-encapsulated c-raf antisense oligodeoxynucleotide"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/liposomal-c-raf-antisense-oligonucleotide/"
}