liposomal CMTR2 inhibitor AT-1965

{
  "id": "MLC-T-ONC-014816",
  "term": "liposomal CMTR2 inhibitor AT-1965",
  "field": "Oncology and biomedicine",
  "definition": "A liposomal formulation containing an inhibitor of cap-specific mRNA (nucleoside-2-O-)-methyltransferase 2 (cap-methytransferase 2; CMTR2; MTR2; FTSJD1), with potential immunomodulating and antineoplastic activities. Upon administration, liposomal CMTR2 inhibitor AT1965 targets, binds to, and inhibits the activity of CMTR2. This causes the innate immune sensors to recognize the mRNA as non-self and results in an anti-viral immune response leading to the activation of B cells and resulting in a B-cell-mediated immune response against tumor cells. This induces tumor cell apoptosis and decreases tumor growth. CMTR2, a key protein in marking newly-synthesized RNA as self, plays a key role in tumor host immunity evasion. Increased expression of CMTR2 correlates with poor prognosis. It is overexpressed in a variety of tumor cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/liposomal-cmtr2-inhibitor-at-1965/"
}