c-raf antisense oligonucleotide ISIS 5132

{
  "id": "MLC-T-ONC-012796",
  "term": "c-raf antisense oligonucleotide ISIS 5132",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation.",
  "synonyms": [
    "ISIS 5132/CGP69846A",
    "RAF-IK antisense ODN",
    "c-RAF antisense"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/c-raf-antisense-oligonucleotide-isis-5132/"
}