Thyrointegrin alphaVbeta3 antagonist fb-PMT

{
  "id": "MLC-T-ONC-017157",
  "term": "Thyrointegrin alphaVbeta3 antagonist fb-PMT",
  "field": "Oncology and biomedicine",
  "definition": "A fluorobenzyl polyethylene glycol (PEG) conjugated to tetraiodothyroacetic acid that targets the thyrointegrin alphaVbeta3, with potential antineoplastic activity. Upon administration, the thyrointegrin alphaVbeta3 antagonist fb-PMT targets and binds to alphaVbeta3 integrin. This results in the inhibition of angiogenesis and metastasis. The mechanism of actions (MOAs) through which fb-PMT exerts its actions may be more complex and may be through multiple signaling pathways. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is overexpressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types.",
  "abbreviation": "fb-PMT",
  "synonyms": [
    "alphaV/beta3 antagonist fb-PMT",
    "fluorobenzyl polyethylene glycol-conjugated tetraiodothyroacetic acid"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/thyrointegrin-alphavbeta3-antagonist-fb-pmt/"
}