Tilarginine

{
  "id": "MLC-T-ONC-017166",
  "term": "Tilarginine",
  "field": "Oncology and biomedicine",
  "definition": "A pan-nitric oxide synthase (NOS) inhibitor, with potential immunomodulating and antineoplastic activities. Upon administration, tilarginine binds to and inhibits NOS, a free radical signaling molecule that promotes angiogenesis, metastasis, and immunosuppression in the tumor microenvironment (TME). Reduction in NOS activity may abrogate the immunosuppressive TME, enhance tumor antigen-specific immune response and inhibit tumor cell proliferation.",
  "abbreviation": "NMA",
  "synonyms": [
    "N5-(methylamidino)-L-ornithine",
    "N-methylarginine",
    "omega-N-monomethylarginine",
    "targinine",
    "NG-monomethyl-L-arginine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tilarginine/"
}