TLR7/8 agonist MEDI9197

{
  "id": "MLC-T-ONC-017207",
  "term": "TLR7/8 agonist MEDI9197",
  "field": "Oncology and biomedicine",
  "definition": "A toll-like receptor type 7 and 8 (TLR7/8) agonist with potential immunostimulating and antitumor activities. Upon intratumoral administration, TLR7/8 agonist MEDI9197 binds to and activates TLR7 and 8, thereby stimulating antigen-presenting cells (APCs), including dendritic cells (DCs). Activation of DCs results in the production of proinflammatory cytokines, and the activation of cytotoxic T-lymphocyte (CTL) and B-lymphocyte immune responses. This may cause tumor cell lysis. TLR7 and 8, members of the TLR family, play fundamental roles in the activation of the immune system.",
  "synonyms": [
    "TLR7/TLR8 dual agonist MEDI9197",
    "Toll-like receptor 7/8 agonist MEDI9197"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tlr7-8-agonist-medi9197/"
}