TLR7 agonist CAN1012

{
  "id": "MLC-T-ONC-017201",
  "term": "TLR7 agonist CAN1012",
  "field": "Oncology and biomedicine",
  "definition": "A Toll-like receptor type 7 (TLR 7) agonist, with potential immunostimulating and antineoplastic activities. Upon intratumoral (IT) administration, TLR7 agonist CAN1012 targets, binds to and activates TLR7, thereby activating TLR7-mediated pathways. This stimulates the maturation and activation of antigen-presenting cells (APCs), including dendritic cells (DCs). Activation of DCs results in the production of pro-inflammatory cytokines, and the activation of cytotoxic T-lymphocyte (CTL)- and B-lymphocyte-mediated immune responses. This may lead to tumor cell lysis. TLR7, a member of the TLR family, plays a fundamental role in the activation of the innate immune system, myeloid cell responses and tumor antigen presentation.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tlr7-agonist-can1012/"
}