TLR7 agonist JNJ-64794964

{
  "id": "MLC-T-ONC-017202",
  "term": "TLR7 agonist JNJ-64794964",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable Toll-like receptor (TLR) 7 agonist, with potential immunostimulating, antiviral and antitumor activities. Upon oral administration, TLR7 agonist JNJ-64794964 specifically targets, binds to and activates TLR7. This triggers anti-viral and anti-tumor activities through the activation of cluster of differentiation (CD) 8-positive T cells, B cells, and innate immune cells including natural killer (NK) cells and macrophages, secretion of interferon alpha (IFNa), and the production of various pro-inflammatory and anti-inflammatory cytokines. TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.",
  "synonyms": [
    "Toll-like receptor 7 agonist AL-034"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tlr7-agonist-jnj-64794964/"
}