Tofacitinib topical cream

{
  "id": "MLC-T-ONC-017224",
  "term": "Tofacitinib topical cream",
  "field": "Oncology and biomedicine",
  "definition": "A topical cream formulation containing the Janus kinase (JAK) inhibitor tofacitinib, with potential immunomodulatory and anti-inflammatory activities. Upon topical administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This may decrease the production of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha (IFN-a) and -beta (IFN-b), and may prevent both an inflammatory response and the inflammation-induced damage caused by certain diseases. JAK are intracellular enzymes involved in signaling pathways affecting hematopoiesis, immunity and inflammation.",
  "synonyms": [
    "tofacitinib cream"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tofacitinib-topical-cream/"
}