topical Nigella sativa seed oil

{
  "id": "MLC-T-ONC-017251",
  "term": "topical Nigella sativa seed oil",
  "field": "Oncology and biomedicine",
  "definition": "A topical preparation containing the oil extracted from the seeds of Nigella sativa, also known as black seed or black cumin, with potential antioxidant, anti-inflammatory and immunomodulatory activities. Upon topical administration of Nigella sativa seed oil, the main constituent thymoquinone may stimulate various cytoprotective antioxidant enzymes. Thymoquinone may also exert anti-inflammatory activity by decreasing the production of inflammation mediators, such as tumor necrosis factor (TNF)-alpha, interleukin (IL) 1-beta and IL-6, and inhibiting pro-inflammatory enzymes, including cyclooxygenase (COX). In addition, thymoquinone may modulate the activity of various immune cells such as T-cells, B-cells, macrophages, neutrophils, natural killer (NK) cells, and dendritic cells (DCs). This may decrease the wound healing process time and may reduce radiation dermatitis upon radiation therapy.",
  "synonyms": [
    "topical N. sativa seed oil",
    "topical black seed oil"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/topical-nigella-sativa-seed-oil/"
}