troxacitabine nucleotide prodrug MIV-818

{
  "id": "MLC-T-ONC-017351",
  "term": "troxacitabine nucleotide prodrug MIV-818",
  "field": "Oncology and biomedicine",
  "definition": "A liver-targeting nucleotide phosphoramidate prodrug of troxacitabine monophosphate (TRX-MP), a dioxolane derivative and L-configuration deoxycytidine analogue, with potential antineoplastic activity. Upon oral administration, MIV-818 is rapidly and specifically hydrolyzed in hepatocytes by liver carboxylesterase 1 (carboxylesterase 1, CE-1), generating high levels of the chain-terminating nucleotide, troxacitabine triphosphate (TRX-TP) in the liver. TRX-TP is then incorporated into tumor cell DNA, leading to termination of DNA synthesis and inhibition of tumor cell proliferation.",
  "synonyms": [
    "troxacitabine prodrug MIV-818"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/troxacitabine-nucleotide-prodrug-miv-818/"
}