Vaccine-sensitized draining lymph node cells

{
  "id": "MLC-T-ONC-017438",
  "term": "Vaccine-sensitized draining lymph node cells",
  "field": "Oncology and biomedicine",
  "definition": "Cells isolated from lymph nodes from patients, and activated in vitro to generate tumor-specific effector T cells. Lymph nodes in the lymphatics draining tumors often contain T cells that are immunologically sensitized but functionally deficient. Vaccine-sensitized draining lymph node cells are prepared by isolating these lymphocytes in vitro and stimulating them with cytokines to differentiate into mature effector cells. Vaccine-draining lymph node cells may also be produced by pharmacological activation of lymph node-derived lymphocytes with drugs such as ionomycin or with bacterial toxin; these activated lymphocytes may be expanded in culture with cytokines such as interleukin-2 prior to infusion into the patient.",
  "abbreviation": "vDLN cells",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vaccine-sensitized-draining-lymph-node-cells/"
}