VDAC/HK2 modulator ointment VDA-1102

{
  "id": "MLC-T-ONC-017468",
  "term": "VDAC/HK2 modulator ointment VDA-1102",
  "field": "Oncology and biomedicine",
  "definition": "A topical ointment formulation containing a voltage-dependent anion channel (VDAC)/hexokinase 2 (HK2) modulator, with potential activity against certain skin cancers. Upon topical application, VDA-1102, as a protein-protein interaction (PPI) disrupter, allosterically binds to HK2, and causes HK2 to dissociate from VDAC, which prevents glycolysis and triggers apoptosis, thereby inhibiting tumor cell growth in VDAC/HK2-expressing tumor cells without affecting the surrounding healthy skin tissue. The VDAC/HK2 system, over-activated in cancer cells, plays a key role in tumor cell proliferation. The VDAC/HK2 association protects cancer cells from apoptosis. HK2 is overexpressed in many malignant cancer tissues that rely on glycolysis, while its expression is limited in normal healthy cells.",
  "synonyms": [
    "VDA-1102 ointment",
    "VDA-1102 topical dermal ointment"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vdac-hk2-modulator-ointment-vda-1102/"
}