VEGFR3 inhibitor EVT801

{
  "id": "MLC-T-ONC-017480",
  "term": "VEGFR3 inhibitor EVT801",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, small molecule inhibitor of human vascular endothelial growth factor receptor 3 (VEGFR3; VEGFR-3; Flt-4), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, VEGFR3 inhibitor EVT801 specifically targets, binds to and inhibits VEGFR3 tyrosine kinase, which may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. EVT801 may also decrease the level of immune suppressive myeloid derived suppressor cells (MDSCs) in the blood, thereby activating anti-tumor immune responses. VEGFR3 plays a critical role in the embryonic vascular system development but is restricted postnatally to endothelial cells of lymphatic vessels and found to be expressed in many solid and hematologic malignancies.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vegfr3-inhibitor-evt801/"
}