anti-VEGFR3 monoclonal antibody IMC-3C5

{
  "id": "MLC-T-ONC-011178",
  "term": "anti-VEGFR3 monoclonal antibody IMC-3C5",
  "field": "Oncology and biomedicine",
  "definition": "A fully-human monoclonal antibody directed against human vascular endothelial growth factor receptor 3 (VEGFR-3; Flt-4) with antiangiogenic activity. Anti-VEGFR-3 monoclonal antibody IMC-3C5 specifically binds to and inhibits VEGFR-3, which may result in inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-3 plays a critical role in the embryonic vascular system development but is restricted postnatally to endothelial cells of lymphatic vessels and found to be expressed in many solid and hematologic malignancies.",
  "synonyms": [
    "anti-VEGFR3 MoAb IMC-3C5"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-vegfr3-monoclonal-antibody-imc-3c5/"
}