Veltuzumab

{
  "id": "MLC-T-ONC-009206",
  "term": "Veltuzumab",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of several types of lymphoma. It binds to the protein CD20, which is found on B cells (a type of immune system cell) and some types of lymphoma cells. This causes the immune system to kill the cancer cells. Veltuzumab is a type of monoclonal antibody. Also called hA20, HCD20, and IMMU-106.",
    "A fully humanized monoclonal antibody directed against the CD20 antigen with potential antineoplastic activity. Following binding, veltuzumab triggers complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) in cells that overexpress CD20. CD20 antigen is a hydrophobic transmembrane protein located on pre-B and mature B lymphocytes."
  ],
  "abbreviation": "MOAB hA20",
  "synonyms": [
    "hA20",
    "HCD20",
    "IMMU-106",
    "monoclonal antibody hA20"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/veltuzumab/"
}