vinorelbine tartrate

{
  "id": "MLC-T-ONC-009244",
  "term": "vinorelbine tartrate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with cisplatin to treat non-small cell lung cancer that is locally advanced or has spread to other parts of the body. It is also being studied in the treatment of other types of cancer. Vinorelbine tartrate stops cancer cells from growing and dividing and may kill them. It is a type of vinca alkaloid.",
    "The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic properties. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent."
  ],
  "abbreviation": "NVB",
  "synonyms": [
    "navelbine ditartrate",
    "vinorelbine ditartrate"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vinorelbine-tartrate/"
}